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Awards to USA For-Profit Entities and Teams for Innovative Biomedical Research and Solutions

Complement-Animal Research in Experimentation (Complement-ARIE) Challenge


GrantWatch ID#

Funding Source
U.S. Department of Health and Human Services (HHS) - National Institutes of Health (NIH)
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Geographic Focus

Important Dates
Conference Date: 12/06/23
Deadline: 01/11/24 Save

Grant Description
Awards of up to $50,000 to USA for-profit entities and teams for innovative biomedical research and solutions. Funding is intended for the development of specific technologies that will more accurately imitate human biology and lead to new, impactful products and that will allow researchers to answer previously unanswerable questions.

This challenge seeks to propel the development and refinement of human-based New Approach Methodologies (NAMs). While traditional models continue to be vital to advancing scientific knowledge, NAMs offer unique strengths that, when utilized correctly or in combination, can expand the toolbox for researchers to answer previously difficult or unanswerable biomedical research questions.

Solutions must include next-generation innovation in in vitro, in silico, or in chemico approaches to emulate human biology or integrations thereof. Solutions must demonstrate substantial advancement from the current state-of-the-art technologies.

Challenge participants will submit a whitepaper demonstrating:

  • Innovation in In Vitro Modeling: Develop advanced human-derived, cell-, or tissue-based models that represent human physiological and pathophysiologic processes across the lifespan. These models should replicate intricate biological reactions and architectural structures, thereby serving as effective platforms for testing, analysis, and prediction.
  • Powering In Silico Models and Simulations: Harness the capabilities of computational tools to create models that can simulate biological responses. These in silico models, backed by robust algorithms, should be capable of analyzing complex datasets, predicting possible outcomes, and aiding in decision-making processes in biomedical research.
  • Exploration of In Chemico Systems: Venture into the realm of cell-free systems that allow researchers to study molecular interactions outside the confines of cellular environments. These systems should provide a clear window into the intricate interactions of molecules, enabling precise studies without cellular interference.
  • NAM Integration: The challenge emphasizes integration of NAMs, either across models or into other platforms. The idea is to create a cohesive solution that leverages multiple methodologies for a comprehensive insight into human biology.


Additional Eligibility Criteria
To be eligible to win a prize under this Challenge, a Participant (whether a Team or an Entity) —

- Shall have registered to participate in the Challenge under the rules promulgated by the National Institutes of Health (NIH) as published in this announcement.

- Shall have complied with all the requirements set forth in this announcement.

- In the case of an Entity, shall be incorporated in and maintain a primary place of business in the United States. In the case of a Team, the Team Leader shall be a citizen or permanent resident of the United States. However, non-U.S. citizens and non-permanent residents can participate as a member of a Team or Entity that otherwise satisfies the eligibility criteria. Non-U.S. citizens and non-permanent residents are not eligible to win a monetary prize (in whole or in part). Their participation as part of a winning Team or Entity, if applicable, may be recognized when the results are announced.

- Shall be 18 years of age or older at the time of submission.

A Participant:
- Shall not be a federal entity or federal employee acting within the scope of their employment.
- Shall not be an employee of the Department of Health and Human Services (HHS, or any other component of HHS) acting in their personal capacity.
- Who is employed by a federal agency or entity other than HHS (or any component of HHS), should consult with an agency ethics official to determine whether the federal ethics rules will limit or prohibit the acceptance of a prize under this Challenge.
- Shall not be a judge of the Challenge, or any other party involved with the design, production, execution, or distribution of the Challenge or the immediate family of such a party (i.e., spouse, parent, stepparent, child, or stepchild).

Pre-Proposal Conference
Join the Complement-ARIE Challenge webinar, Dec 6 at 12:00-1:00 PM ET. Click here to register:

Pre-Application Information
- Pre-registration opens: 10/05/23
- Challenge Launch: 11/07/23
- Submission Deadline: 01/11/24
- Submission Judging: 01/11/24 - 02/16/24
- Winner Announcements: February 2024

When are alternatives to animals used in research:


Watch the webinar recording from December 6, 2023:

Additional Funding Information

Estimated Total Program Funding:


Number of Grants
Up to 20

Estimated Size of Grant
Up to $50,000

Contact Information
To apply online, click "Solve This Challenge" at the Full Text Grant RFP link.

RFP & Supporting Documents
Full Grant Text RFP

Before starting your grant application, please review the funding source's website listed below for updates / changes / addendums / conferences / LOIs.

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