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Grants to USA, Canada, and International Investigators to Conduct Innovative Research on Epilepsy

CURE Epilepsy Award


GrantWatch ID#

Funding Source
Array ( [0] => American Samoa (USA); [1] => Guam (USA); [2] => Puerto Rico (USA); [3] => Virgin Islands (USA); [4] => Northern Mariana Islands (USA); )

Geographic Focus
USA Territories: American Samoa (USA);   Guam (USA);   Puerto Rico (USA);   Virgin Islands (USA);   Northern Mariana Islands (USA);
USA Compact Free Associations:The Federated States of Micronesia (USA)   Marshall Islands (USA)   Republic of Palau (USA)
International, Israel and Canada.

Important Dates
LOI Date: 01/09/24
Deadline: 03/26/24 9:00 PM ET Save

Grant Description
Grants to USA, Canada, and International investigators for research studies focused on epilepsy. Interested applicants are required to submit a letter of intent prior to the full proposal. Funding is intended to support transformative projects by established and early-career researchers that address prevention, elimination, and disease modification.

The CURE Epilepsy Award reflects CURE Epilepsy’s continued focus on scientific advances that have the potential to truly transform the lives of those affected by epilepsy, with prevention and disease modification as critical goals. Key priority areas for the award include: 1) Basic mechanisms of epilepsy; 2) Acquired epilepsies; 3) Pediatric epilepsies; 4) SUDEP; 5) Treatment-resistant epilepsies; and 6) Sleep & epilepsy.

CURE Epilepsy encourages applications from groups underrepresented in the biomedical, clinical, behavioral, and social sciences. These groups include individuals with disabilities, veterans, persons from underrepresented racial and ethnic groups and gender diverse groups, women in biomedical-related disciplines, or any legally protected characteristic. 

The following priority areas reflect CURE Epilepsy’s focus on advances that have the potential to truly transform and save lives:

  • Transformative research to enhance understanding of the cellular, molecular, genetic, and systems-level mechanisms that lead to any of the epilepsies, facilitating the continued investigation of disease-modifying or preventative strategies.
  • Innovative approaches that can prevent, modify and/or arrest the development of acquired epilepsy. Examples include epilepsy that develops after stroke, tumor, traumatic brain injury or infection, including febrile infection-related epilepsy syndrome (FIRES) as well as new-onset refractory status-epilepticus (NORSE).
  • Research that will inform the development of novel therapies to prevent onset or halt the progression of the severe pediatric epilepsies.
  • Research focused on new, effective treatments for the >30% of the epilepsy population who are pharmacoresistant.
  • Novel research that furthers understanding of the causes and ultimate elimination of SUDEP.
  • Translational, clinical, and clinically informed basic research that will facilitate understanding of the cellular-, molecular-, and systems-level mechanisms that underlie the relationships between sleep and epilepsy.

Funding requests may include salary support for the Principal Investigator (PI), co-PIs, technical staff, supplies, animal costs, publication fees and travel to an epilepsy-related conference if the PI is presenting his/her CURE Epilepsy-funded research. Limited equipment purchases that are required to complete goals will be considered.

For additional information, see:


Additional Eligibility Criteria
This award is available to both established and early-career investigators. Generally, early-career investigators are university faculty at the assistant professor level (or hold an equivalent position in a non-university research organization). Established investigators are university faculty at the associate professor level or above.

International applicants are welcome.

Researchers who serve on CURE Epilepsy’s Scientific Advisory Council are ineligible to apply for or sponsor a grant for the duration of their term.

Post-doctoral fellows may not apply for this award.

Based on CURE Epilepsy’s current research objectives, lower priority will be given for
research in the following areas:
- Research that focuses solely on a comorbid condition without also seeking to
address/understand the accompanying epilepsy.
- Research that focuses solely on improving localization of the epileptic seizure focus

Indirect costs are not supported.

Funds cannot be used to cover institutional expenses such as network charges, computer maintenance and services, insurance dues or other miscellaneous expenses not directly related to performing the project.

Pre-Application Information
Key Dates:
- Request for Proposals: Monday, November 27, 2023
- Letter of Intent Deadline: Tuesday, January 9, 2024, 9 PM ET
- Full Application Invitations: Tuesday, February 20, 2024
- Full Application Deadline: Tuesday, March 26, 2024, 9 PM ET
- Anticipated Award Announcement: July 2024
- Anticipated Project Start Date: September 2024

All applicants must submit a Letter of Intent (LOI). Following review of LOIs, select applicants will be invited to submit full proposals.

All materials must be submitted in English.

There is no limit to the number of researchers from the same institution who can apply for the same grant.

Grantees cannot receive funding on two different awards at the same time.

Grant Process:

For additional relevant links, see the Full Grant Text RFP link.

Estimated Size of Grant
Requests may be made for up to a total of $250,000 paid over 2 years.

Term of Contract
- Grants may be paid over 2 years.
- Anticipated Project Start Date: September 2024
- CURE Epilepsy does not provide deadline extensions.

Contact Information
Submit the LOI and, if invited, the full application online:

Questions should be directed to the Research Team at or 312-255-1801.

420 N. Wabash Avenue, Suite 650
Chicago, IL 60611

Mailing address:
PO Box 10572
Chicago, IL 60610

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